Mohammed Hashmat Ali
Southeast Missouri State University, USA
Title: Synthesis of N-Aryl and N-Alkyl pyrroles promoted by microwave irradiation
Biography
Biography: Mohammed Hashmat Ali
Abstract
As a part of our research envevour in green chemistry we have devised a microwave-promoted synthesis of N-substituted pyrroles. Pyrroles are an important class of heterocyclic compounds with various biological activities. They are known to have anti-malerial, anti-inflammatory, antibacterial, antihypertensive and other biological properties. Pyrroles are structural units in many natural products including heme, chlorophyll, bile pigments and cytochromes. Many methods for the synthesis of substituted pyrroles have been described in the leterature. Synthesis of pyrrole utilizing Hantzsch, Knorr, Aza-Wittig and Paul-Knorr methods are frequently reported in the literature. The Paal-Knorr method has been known since 1885 and still remains an attractive pathway for the synthesis of N-substituted pyrroles but requires long reaction times. In an effort to simplify the synthesis of N-substituted pyrroles, we developed a microwave-assisted method for the synthesis of these compounds from 2,5-dimethoxytetrahydrofuran and primary amines. Our method avoids using any toxic catalyst and produces high product yields in short time. Most often a simple filtration through a short silica gel column produced analytically pure product. The results and efficacy of our microwave method for pyrrole synthesis will be presented at the meeting.