Hideki Amii
Gunma University, Japan
Title: Recent progress in catalytic aromatic trifluoromethylation
Biography
Biography: Hideki Amii
Abstract
Trifluoromethylated aromatic compounds are the substances of considerable interest in various industrial fields. Owing to the increasing demands for fluoroaromatics, new methodologies for aromatic trifluoromethylation have been required from the viewpoints of cost, simplicity, efficiency, versatility, and environmental benignity including a catalytic process. Herein, we present catalytic aromatic trifluoromethylation via ï¢-carbon elimination. Fluoral (trifluoroacetaldehyde) and its derivatives are readily available compounds. Hemiaminals of fluoral are known to be convenient sources of trifluoromethyl anion. We developed a catalytic procedure for aromatic trifluoromethylation by the use of trifluoroacetaldehyde hemiaminal derivatives as a cross-coupling partner. Furthermore, the cross-coupling reactions employing trifluoromethylated carbinols will be disclosed.