Lina Zhao
Institute of High Energy Physics, Chinese Academy of Sciences, China
Title: Molecular structure and targeting mechanism study for the green synthesized peptide coated gold nanocluster
Biography
Biography: Lina Zhao
Abstract
The peptide coated gold nanocluster (AuNC) can be synthesized by green chemical technique. The peptide coated AuNC has precise chemical formula and molecular structure, which are critical to its unique nanotechnological applications of targeting specific proteins either for protein analysis or drug design. Here we designed and studied the molecular structure and electronic structure of the peptide coated AuNC by the theoretical method for the first time. Furthermore, we identified the coating peptide sequence and studied the specific binding mechanism of peptide coated AuNC to target protein. From the results, we proposed a universal approach to control the chemicophysical properties of AuNC by the coating interface. Based on the biocompatible AuNC, the coating peptide sequence design and its targeting molecular mechanism could develop a series of novel peptide coated AuNC targeting systems. We brought a new insight from theoretical viewpoint to the targeting detection and targeting nanomedicine researches in green nanotechnology.