Past and Present Research Systems of Green Chemistry

Biography

Biography: Virendra K Rathod

Abstract

Enzymes are preferred over chemical catalyst for the synthesis of various chemicals as it requires mild reactions conditions. Additionally since enzyme catalysed processes do not generate any waste material due to high slectvity of enzyme, the process can be labelled as “Green Procss”. This work deals with synthesis of cinnaamyl adipate by esterification between Cinnamyl alcohol and adipic acid catalyzed by immobilized lipase B from Candida Antarctica, commercially known as Novozym 435 in a conventional batch reactor using standard mechanical mixing and in solvent free system. Effects of various parameters such as nature of lipase, speed of agitation, mole ratio, catalyst loading, temperature and reusability of catalyst on the conversion was studied and optmized. Overall conversion of 94.05% was achieved at optimized contitions as reaction time of 12 h, mole ratio of adipic acid to cinnamyl alcohol of 1:3, catalyst loading 1% and reaction temperature of 60°C. It is also observed that the enzyme can be recycled seven times without marginal loss of enzyme activity. To the best of our knowledge, this is first report where enzyme is used as a catalyst for sythesis of cinnamyl adipate. From the progress curve analysis, it was established that the reaction followed the random bi-bi mechanism. There was an excellent agreement between the experimental data and stimulated data. This work will be very useful for synthesis of cinnamyl adipate and many other such chemicals via green route as well as design of batch rector.