Sharda Goel
Maharshi Dayanand University, India
Title: An efficient and versatile method for synthesis of 1,4-Dihydropridines at mild reaction conditions
Biography
Biography: Sharda Goel
Abstract
Polyhydroquinolines are fused heterocyclic compounds which exhibits bactericidal, fungicidal, analgestic and anti-inflammatory activities and act as hypotensive and anticancer agents. Due to their biological importance, there has been considerable interest in developing new synthetic methods for the preparation of polyhydriquinolines. Herein as a part of our efforts to develop new synthetic method in heterocyclic chemistry, we report an environmentally benign, efficient and convenient protocol for the synthesis of derivatives of polyhydroquinoline by combining dimedone, ethylacetoacetate and ammonium acetate with various substituted arylaldehydes in good to excellent yields by a grinding method under solvent-free conditions. The process is simple, straightforward, environmentally benign and easily leads to the synthesis of desired polyhydroquinolines i.e ethyl 4-phenyl-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylate. The catalyst is easily available and inexpensive. This method proves to be advantageous in terms of excellent yields and short reaction times. In recent years, with the emphasis on adoption of cleaner green chemistry processes, a tremendous interest has been observed in carrying out various chemical transformations under heterogenous conditions owing to simplicity in operation. Among phase transfer catalysts, TEBAC (triethylbenzylammoniumchloride) has gained immense popularity in organic synthesis in last few decades. Owing to all the advantages of TEBAC, the development of TEBAC catalysed organic reactions is still an attractive research area in the coming future.