Past and Present Research Systems of Green Chemistry

Biography

Biography: Jaya Parkash Yadav

Abstract

Nanobiotechnology is presently one of the most dynamic and important disciplines of research in contemporary material science whereby plants and different plant products are finding an imperative use in the synthesis of nanoparticles (NPs). In recent years, researchers have drawn their attention towards ecofriendly synthesis of nanoparticles and their activity against different kinds of microbes. In recent study, silver nanoparticles were successfully synthesized from aqueous extract of Phyllanthus amarus, an important medicinal plant in ayurveda. Silver nanoparticles were characterized by UV-Vis spectroscopy, transmission electron microscopy; energy dispersive X-ray spectroscopy, dynamic light scattering, zeta potential, X- ray diffraction and fourier transform infra-red spectroscopy. The average size of synthesized nanoparticles was 15.7, 24±8 and 29.78nm by XRD, TEM and DLS respectively. The antibacterial activity of silver nanoparticles was investigated against nine reference bacterial ATCC strains and ten multidrug resistant strains of Pseudomonas aeruginosa isolated from burn patients. The zone of inhibition was measured in the range of 10± 0.58mm to 17±0.11mm against reference strains and 10±0.53 to 21±0.11mm against MDR burn isolates with silver nanoparticles concentration of 12.5 to 100μg/ml. The zone of inhibition increased with increase in the concentration of silver nanoparticles. The minimum inhibitory concentration values of synthesized silver nanoparticles were found in the range of 6.25 to 25μg/ml against reference strains and 6.25 to 12.5μg/ml against MDR burn isolates which are comparable with the standard antibiotics. The silver nanoparticles from P. amarus extract exhibited excellent antibacterial potential against wide range of microbes including MDR strains, give insight of their potential applicability as an alternative antibacterial in the health care system and also justify the therapeutic efficacy of P. amarus. It is concluded that this green chemistry approach toward the synthesis of AgNPs possesses several advantages viz, easy process by which this may be scaled up, economic viability, etc. An application of such eco-friendly nanoparticles as bactericidal makes this method potentially stimulating for the large scale synthesis of other inorganic materials, like nanomaterials.