Biography
Biography: Diego Gamba Sánchez
Abstract
Amides are incontestably one of the most important functional groups in organic chemistry; they are present in a huge number of natural occurring structures and synthetic molecules with diverse usages. Besides amide synthesis by classical methods is one of the most used synthetic procedures in pharmaceutical industry, on the other hand ACS has recognized atom economy in amide synthesis as on the most important challenges to overcome in synthetic organic chemistry. The research described in this presentation will underline fundamental problems in amide synthesis and will also show different approaches using catalyst for transamidation of carboxamides, transamidation of thioamides and direct amidation of carboxylic acids. These three methodologies can be placed in a green context and will be discussed as alternative atom economic procedures for classical methods in amide synthesis.