Miguel Yus
University of Alicante, Spain
Title: Atom and Step Economy in Synthetic Organic Chemistry
Biography
Biography: Miguel Yus
Abstract
One important task concerning any chemical process has to do with the so-called atomic efficiency (AE), which can modify considerably the concept of yield corresponding to a chemical reaction: even working with a high chemical yield a reaction can be not efficient when the main part of the reactants structure is not included in the final product. Two interesting processes will be the subject of this presentation: (a) The hydrogen autotransfer reaction, in which an alcohol is used as electrophilic component, for instance, in the alkylation of a carbonyl compound, water being the only byproduct in the process, that is, therefore, of great value from an atom efficiency point of view; and (b) the multicomponent reaction, such as the aza-Sakurai reaction, or the diastereoselective allylation of imines, of considerable interest from a step efficiency point of view.
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